Home. Microcrystalline Cellulose / Avicel PH-102. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. In 1964 FMC, Corporation . Microcrystalline Cellulose NF. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. undefined. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Fiber supplements can lessen the absorption of some . stream w !1AQaq"2B #3Rbr Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Meet our leadership team. >> Alginates also function as actives in some anti-reflux products. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . The table below shows the most common physicochemical parameters of this raw material. >> The typical mean particle size is 20200 m. Apply today! The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. : 5. 6 0 obj Synergies to simplify formulation challenges and reduce operational costs. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. 51395-75-6 Avicel RC 591. % Material safety data sheet - FMC Corporation. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. CAS 9004-34-6. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. MATERIAL SAFETY DATA SHEET. cas:9000-11-7 msds Carboxymethyl cellulose. Watch Now. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. These grades have particle sizes ranging from <30 to approximately 200. Medium size standard MCC grade, suited for the majority of directly compressible actives. CAS 9004-34-6, pH 5 - 7.5. : 1. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Created Date: 2/10/2020 8:51:41 PM . Microcrystalline Cellulose; Cellulose; Functions. cas:9032-51-3 msds CELLULOSE PAB. /Parent 3 0 R 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Regulatory Information As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. A family of polysaccharide products that allow distinctive drug delivery solutions. Test Data Available. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. : 160182 Date Approved: 05/25/2010 Revision No. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. %PDF-1.4 There have always been two different points of view for the liquidity of MCC. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. However, it yields non-digestible fibre. 9,LL!z $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. We are artists at heart and creators by nature. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Have an order or account question? It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Microcrystalline Cellulose (MCC) MSDS 1. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Origin(s): Plant/Botanical. /Type/Page Gloves, eye protection and a dust mask should be used. It is available in different grades and particle sizes. Truly distinctive drug delivery solutions. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. The short-term limit for total inhalable dust is 20 mg/m3. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Catalog Number 102331. G2W4de=u183KGH{ vQ#4:1\wc Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Microcrystalline Cellulose E460 MSDS 1. Your file is uploaded and ready to be published. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . (Microcrystalline Cellulose Market Pr. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. endobj Instead, they obtained a stable colloidal suspension. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. We respect your privacy FMC Privacy Policy. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. }o]X4]. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . HMo@9, U Q!R/1*;` As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. SUBSTANCE IDENTIFICATION 1.1. : 160182. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. LOT #: Available upon request. SUBSTANCE IDENTIFICATION 1.1. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Buy Chemicals. It is, however, a good source of fibre. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. q86@on$^X_HuH;3` CAS No. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. X\o^ Powder becomes slippery when wet. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. <> The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. stream Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe It is also used in plaque assays for counting. Wu, K. Zuurman, H.W. MCC helps in the formation of spheres because of its . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. 1.3. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. If you are already a ChemPoint customer then sign up for access to our online ordering website. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Micro Crystalline Cellulose. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Quantity: 1 700 kgs. 0.25 - 0.37. . . Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Doses up to 30 g per day appear to be . ChemicalBook. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. 102331. No. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? <> LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Quick Links. However, consumption of large quantities of the material may have a laxative effect. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. 4 0 obj Manufactured by: China . FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Document(s): certificate data msds. In large quantities it provides dietary bulk and may lead to a laxative effect. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Production of Pharmaceutical Grade Microcrystalline Cellulose. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Packaging: 34 x 50 kgs fiber drums. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Heavy metals, % NMT 0.001 LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Go to Investor Relations. It . Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . This Microcrystalline Cellulose . The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. No. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. ( The data shown below apply only to Avicel PH 101. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ gac74 [#B6`Wnw7 In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. All Rights Reserved. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. EMCOCEL 90 M. 130. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. High performance lubricant that brings more to the tablet. We can send by Fedex, by ship or by plane according to international rules. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. xv}O2' H~KEe9>G/,:9\i It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. B;vLZpHU%ChUyD+[ The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. SDS. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent .
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